Acute myeloid leukemia arising from a donor derived premalignant hematopoietic clone: A possible mechanism for the origin of leukemia in donor cells Journal Article

   

Authors:	Dickson, M. A.; Papadopoulos, E. B.; Hedvat, C. V.; Jhanwar, S. C.; Brentjens, R. J.
Article Title:	Acute myeloid leukemia arising from a donor derived premalignant hematopoietic clone: A possible mechanism for the origin of leukemia in donor cells
Abstract:	During recent years, it has become increasingly evident that donor leukemia following allogeneic transplant may be more common then realized in the past. We identified five cases of potential donor leukemia cases during past five years. The precise mechanism of the origin of such leukemias, however, remains poorly defined. In this short communication, we report a well documented case of donor-derived de novo acute myeloid leukemia (AML) that developed fourteen years after allogeneic stem cell transplantation for treatment induced AML for his primary malignancy Immunoblastic lymphoma. This case allows us to postulate a possible mechanism of the origin of donor leukemia. The de novo AML clone contained a distinct cytogenetic abnormality, trisomy 11, which was simultaneously detected in preserved peripheral blood obtained at the time of transplantation as well as in the current bone marrow from an otherwise clinically and phenotypically normal donor. The findings from this unique case, provides insight into the process of leukemogenesis, and suggests that the sequence of events leading to leukemogenesis in this patient involved the senescence/apoptosis of normal donor hematopoietic cells due to telomere shortening resulting in the selective proliferation and transformation of this clone with MLL (mixed-lineage leukemia) gene amplification.
Keywords:	adult; human tissue; acute granulocytic leukemia; prednisone; fatigue; cancer recurrence; case report; doxorubicin; cytarabine; methotrexate; flow cytometry; gene amplification; etoposide; cytogenetics; cyclophosphamide; hemoglobin; vincristine; allogenic bone marrow transplantation; chimera; cancer regression; whole body radiation; fluorescence in situ hybridization; bone marrow biopsy; epigenetics; leukemogenesis; hematopoietic cell; thrombocyte count; bleomycin; living donor; leukocyte count; idarubicin; karyotype; trisomy; precancer; skin bruising; telomere homeostasis; human; male; article; immunoblastic lymphoma; acute secondary leukemia; allogeneic bone marrow transplantation; donor leukemia; origin of donor leukemia mechanism; telomere length in translantation; trisomy 11
Journal Title:	Leukemia Research Reports
Volume:	3
Issue:	2
ISSN:	2213-0489
Publisher:	Elsevier Inc.
Date Published:	2014-01-01
Start Page:	38
End Page:	41
Language:	English
DOI:	10.1016/j.lrr.2014.04.001
PROVIDER:	scopus
PMCID:	PMC4050285
PUBMED:	24918066
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84907600795&partnerID=40&md5=6634f690746f8d7ac47ab2a543ec44a6
Notes:	Export Date: 3 November 2014 -- Source: Scopus

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