Immune reconstitution in the aging host: Opportunities for mechanism-based therapy in allogeneic hematopoietic cell transplantation Review
| Authors: | Lin, R. J.; Elias, H. K.; van den Brink, M. R. M. |
| Review Title: | Immune reconstitution in the aging host: Opportunities for mechanism-based therapy in allogeneic hematopoietic cell transplantation |
| Abstract: | Older patients with hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation with encouraging outcomes. While aging-related thymic dysfunction remains a major obstacle to optimal and timely immune reconstitution post- transplantation, recent accumulating evidence has suggested that various aging hallmarks such as cellular senescence, inflamm-aging, and hematopoietic stem cell exhaustion, could also impact immune reconstitution post-transplantation in both thymic-dependent and independent manner. Here we review molecular and cellular aspects of immune senescence and immune rejuvenation related to allogeneic hematopoietic cell transplantation among older patients and discuss potential strategies for mechanism-based therapeutic intervention. © Copyright © 2021 Lin, Elias and van den Brink. |
| Keywords: | adult; human tissue; review; allogeneic hematopoietic stem cell transplantation; aging; cell aging; rejuvenation; immune reconstitution; mitochondrial dysfunction; cellular senescence; human; allogeneic hematologic stem cell transplantation |
| Journal Title: | Frontiers in Immunology |
| Volume: | 12 |
| ISSN: | 1664-3224 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2021-04-01 |
| Start Page: | 674093 |
| Language: | English |
| DOI: | 10.3389/fimmu.2021.674093 |
| PUBMED: | 33953731 |
| PROVIDER: | scopus |
| PMCID: | PMC8089387 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2021 -- Source: Scopus |
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