Immunohistologic dissection of the human kidney using monoclonal antibodies Journal Article

  


Authors: Bander, N. H.; Cordon-Cardo, C.; Finstad, C. L.; Whitmore, W. F. Jr; Vaughan, E. D. Jr; Oettgen, H. F.; Melamed, M.; Old, L. J.
Article Title: Immunohistologic dissection of the human kidney using monoclonal antibodies
Abstract: Nine murine monoclonal antibodies which detect differentiation antigens of the human kidney are described. Immunofluorescence and immunoperoxidase studies demonstrate that these antigens are expressed by different cell types comprising the nephron. Monoclonal antibody MA99 detects a glycoprotein complex of the glomerular basement membrane. Monoclonal antibody S4 detects a glycoprotein of 160,000 daltons (gp160) expressed by glomerular and proximal tubular epithelial cells. Monoclonal antibodies S23, S27, and S6 immunoprecipitate a glycoprotein of 120,000 daltons (gp120) found on cells of the proximal tubule and portions of Henle's loop. Monoclonal antibody C26 identifies a glycoprotein of 40,000 daltons (gp40) expressed by cells of the distal and collecting tubules. Monoclonal antibodies M2 and S8 are specific for A and B blood group antigens, respectively, found on cells of the collecting tubule in individuals of the respective blood type. This panel of antibodies is useful in the study of normal renal embryogenesis, microanatomy and physiology as well as pathological processes including tumors.
Keywords: nonhuman; mouse; embryo; animal experiment; embryo development; immunofluorescence; physiology; monoclonal antibody; kidney; diagnosis; tumor; glycoprotein; human; priority journal; kidney tubule epithelium; blood group antigen; glomerulus basement membrane; blood and hemopoietic system
Journal Title: Journal of Urology
Volume: 133
Issue: 3
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1985-03-01
Start Page: 502
End Page: 505
Language: English
DOI: 10.1016/s0022-5347(17)49041-0
PROVIDER: scopus
PUBMED: 3883008
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021905727&doi=10.1016%2fS0022-5347%2817%2949041-0&partnerID=40&md5=e3aaccf08428264999b9d79a1d73b215
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Neil Harrison Bander
    62 Bander
  3. Herbert F Oettgen
    130 Oettgen
  4. Lloyd J Old
    593 Old
  5. Willet F. Whitmore Jr
    139 Whitmore
  6. Connie L. Finstad
    45 Finstad
  7. Myron Melamed
    148 Melamed
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