Planar polarity and tissue morphogenesis Journal Article


Author: Zallen, J. A.
Article Title: Planar polarity and tissue morphogenesis
Abstract: Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use directional cues provided locally by communication between neighboring cells. This review describes our current understanding of the mechanisms that transmit directional signals from cell to cell and compares the strategies for generating global systems of spatial information in stationary and dynamic cell populations. © 2007 Elsevier Inc. All rights reserved.
Keywords: signal transduction; review; nonhuman; molecular genetics; protein function; protein localization; animals; cell division; cell function; models, biological; molecular dynamics; drosophila; morphogenesis; cell population; cell type; stem cell; gene expression regulation, developmental; membrane protein; cell polarity; molecular interaction; epithelium; microtubule; cell communication; body patterning; sense organ; frizzled protein; body surface; anterior posterior axis; frizzled receptors; cytoplasm protein
Journal Title: Cell
Volume: 129
Issue: 6
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2007-06-15
Start Page: 1051
End Page: 1063
Language: English
DOI: 10.1016/j.cell.2007.05.050
PUBMED: 17574020
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 131" - "Export Date: 17 November 2011" - "CODEN: CELLB" - "Source: Scopus"
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  1. Jennifer A Zallen
    39 Zallen