Multicellular rosette formation links planar cell polarity to tissue morphogenesis Journal Article
| Authors: | Blankenship, J. T.; Backovic, S. T.; Sanny, Justina S. P.; Weitz, O.; Zallen, J. A. |
| Article Title: | Multicellular rosette formation links planar cell polarity to tissue morphogenesis |
| Abstract: | Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture that provides the basis for directional cell behavior. We find that planar polarity in the Drosophila embryo is established through a sequential enrichment of actin-myosin cables and adherens junction proteins in complementary surface domains. F-actin accumulation at AP interfaces represents the first break in planar symmetry and occurs independently of proper junctional protein distribution at DV interfaces. Polarized cells engage in a novel program of locally coordinated behavior to generate multicellular rosette structures that form and resolve in a directional fashion. Actin-myosin structures align across multiple cells during rosette formation, and adherens junction proteins assemble in a stepwise fashion during rosette resolution. Patterning genes essential for axis elongation selectively affect the frequency and directionality of rosette formation. We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; controlled study; nonhuman; protein domain; protein function; protein localization; animals; actin; cell function; embryo; alleles; drosophila; embryo pattern formation; morphogenesis; embryo, nonmammalian; quantitative analysis; cell movement; epithelial cells; green fluorescent proteins; cellbio; devbio; cell polarity; rosette formation; immunofluorescence test; protein structure; f actin; actins; cell interaction; beta catenin; cadherin; cadherins; myosin; myosin type ii; drosophila proteins; body patterning; gap junction protein; adherens junctions; developmental genetics; embryo axis; cytoarchitecture |
| Journal Title: | Developmental Cell |
| Volume: | 11 |
| Issue: | 4 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2006-10-01 |
| Start Page: | 459 |
| End Page: | 470 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2006.09.007 |
| PUBMED: | 17011486 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 131" - "Export Date: 4 June 2012" - "CODEN: DCEEB" - "Source: Scopus" |
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