Translating cell polarity into tissue elongation Journal Article


Authors: Vichas, A.; Zallen, J. A.
Article Title: Translating cell polarity into tissue elongation
Abstract: Planar cell polarity, the orientation of single-cell asymmetries within the plane of a multicellular tissue, is essential to generating the shape and dimensions of organs and organisms. Planar polarity systems align cell behavior with the body axes and orient the cellular processes that lead to tissue elongation. Using Drosophila as a model system, significant progress has been made toward understanding how planar polarity is generated by biochemical and mechanical signals. Recent studies using time-lapse imaging reveal that cells engage in a number of active behaviors whose orientation and dynamics translate planar cell polarity into tissue elongation. Here we review recent progress in understanding the cellular mechanisms that link planar polarity to large-scale changes in tissue structure. © 2011 Elsevier Ltd.
Keywords: review; nonhuman; animals; cell function; cell structure; molecular dynamics; drosophila; molecular mechanics; embryo, nonmammalian; cell polarity; cell count; drosophila melanogaster; biochemistry; microtubules; cell adhesion; myosin; cell elongation; adhesion; elongation; egg; planar polarity
Journal Title: Seminars in Cell and Developmental Biology
Volume: 22
Issue: 8
ISSN: 1084-9521
Publisher: Elsevier Inc.  
Date Published: 2011-10-01
Start Page: 858
End Page: 864
Language: English
DOI: 10.1016/j.semcdb.2011.09.013
PROVIDER: scopus
PUBMED: 21983030
PMCID: PMC4752253
DOI/URL:
Notes: --- - "Export Date: 3 January 2012" - "CODEN: SCDBF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Jennifer A Zallen
    39 Zallen
  2. Atheana Vichas
    6 Vichas