An LRR receptor-teneurin system directs planar polarity at compartment boundaries Journal Article
| Authors: | Paré, A. C.; Naik, P.; Shi, J.; Mirman, Z.; Palmquist, K. H.; Zallen, J. A. |
| Article Title: | An LRR receptor-teneurin system directs planar polarity at compartment boundaries |
| Abstract: | Epithelial cells dynamically self-organize in response to extracellular spatial cues relayed by cell-surface receptors. During convergent extension in Drosophila, Toll-related receptors direct planar polarized cell rearrangements that elongate the head-to-tail axis. However, many cells establish polarity in the absence of Toll receptor activity, indicating the presence of additional spatial cues. Here we demonstrate that the leucine-rich-repeat receptor Tartan and the teneurin Ten-m provide critical polarity signals at epithelial compartment boundaries. The Tartan and Ten-m extracellular domains interact in vitro, and Tartan promotes Ten-m localization to compartment boundaries in vivo. We show that Tartan and Ten-m are necessary for the planar polarity and organization of compartment boundary cells. Moreover, ectopic stripes of Tartan and Ten-m are sufficient to induce myosin accumulation at stripe boundaries. These results demonstrate that the Tartan/Ten-m and Toll receptor systems together create a high-resolution network of spatial cues that guides cell behavior during convergent extension. © 2019 Elsevier Inc. Compartment boundaries are conserved structures that prevent cell mixing in multicellular tissues. Paré et al. show that a system involving the LRR receptor Tartan and its teneurin ligand Ten-m position these boundaries by directing the subcellular localization of cytoskeletal regulators. © 2019 Elsevier Inc. |
| Keywords: | controlled study; unclassified drug; nonhuman; animal cell; cell function; embryo; protein depletion; protein protein interaction; protein; morphogenesis; in vitro study; in situ hybridization; epithelium cell; cellular distribution; cell polarity; receptor; cell shape; cell adhesion; receptor gene; open reading frame; proteinase activated receptor 3; planar polarity; convergent extension; epithelia; priority journal; article; boundary; clustered regularly interspaced short palindromic repeat; toll receptor; lrr receptor; teneurin; leucine rich repeat receptor; tartan |
| Journal Title: | Developmental Cell |
| Volume: | 51 |
| Issue: | 2 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2019-10-21 |
| Start Page: | 208 |
| End Page: | 221.e6 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2019.08.003 |
| PUBMED: | 31495696 |
| PROVIDER: | scopus |
| PMCID: | PMC8415256 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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