Applications of total synthesis toward the discovery of clinically useful anticancer agents Journal Article
| Authors: | Wilson, R. M.; Danishefsky, S. J. |
| Article Title: | Applications of total synthesis toward the discovery of clinically useful anticancer agents |
| Abstract: | This tutorial review provides a historical sampling of synthetic efforts undertaken in our laboratory, which have led to the total syntheses of a range of small molecule natural products of potential interest in oncology. It has become evident that natural products, and structures clearly derivable from natural products, have a remarkable record in the treatment of cancer at the clinical level. It is likely that, with the growing power of chemical synthesis, small molecule natural products will play a continuing role in providing lead anticancer compounds. © The Royal Society of Chemistry 2007. |
| Keywords: | unclassified drug; antineoplastic agents; antineoplastic agent; enzyme inhibitor; chemistry; enzyme inhibitors; antibiotics, antineoplastic; mitomycin; antineoplastic antibiotic; macrolide; synthesis; tubulin modulator; tubulin modulators; isoquinoline derivative; macrolides; isoquinolines; amaryllidaceae alkaloid; pancratistatin; amaryllidaceae alkaloids; mitomycins |
| Journal Title: | Chemical Society Reviews |
| Volume: | 36 |
| Issue: | 8 |
| ISSN: | 0306-0012 |
| Publisher: | Royal Society of Chemistry |
| Date Published: | 2007-08-01 |
| Start Page: | 1207 |
| End Page: | 1226 |
| Language: | English |
| DOI: | 10.1039/b611967k |
| PUBMED: | 17619682 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: CSRVB" - "Source: Scopus" |
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