Small molecule inhibition of microbial natural product biosynthesis - An emerging antibiotic strategy Journal Article
| Authors: | Cisar, J. S.; Tan, D. S. |
| Article Title: | Small molecule inhibition of microbial natural product biosynthesis - An emerging antibiotic strategy |
| Abstract: | A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy. © The Royal Society of Chemistry. |
| Keywords: | review; methodology; metabolism; biological model; models, biological; enzyme inhibitor; drug design; biosynthesis; antiinfective agent; anti-bacterial agents; enzyme inhibitors; biological product; biological products; combinatorial chemistry; combinatorial chemistry techniques; pharmaceutics; technology, pharmaceutical |
| Journal Title: | Chemical Society Reviews |
| Volume: | 37 |
| Issue: | 7 |
| ISSN: | 0306-0012 |
| Publisher: | Royal Society of Chemistry |
| Date Published: | 2008-01-01 |
| Start Page: | 1320 |
| End Page: | 1329 |
| Language: | English |
| DOI: | 10.1039/b702780j |
| PUBMED: | 18568158 |
| PROVIDER: | scopus |
| PMCID: | PMC2587208 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: CSRVB" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work