Small molecule inhibition of microbial natural product biosynthesis - An emerging antibiotic strategy Journal Article


Authors: Cisar, J. S.; Tan, D. S.
Article Title: Small molecule inhibition of microbial natural product biosynthesis - An emerging antibiotic strategy
Abstract: A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy. © The Royal Society of Chemistry.
Keywords: review; methodology; metabolism; biological model; models, biological; enzyme inhibitor; drug design; biosynthesis; antiinfective agent; anti-bacterial agents; enzyme inhibitors; biological product; biological products; combinatorial chemistry; combinatorial chemistry techniques; pharmaceutics; technology, pharmaceutical
Journal Title: Chemical Society Reviews
Volume: 37
Issue: 7
ISSN: 0306-0012
Publisher: Royal Society of Chemistry  
Date Published: 2008-01-01
Start Page: 1320
End Page: 1329
Language: English
DOI: 10.1039/b702780j
PUBMED: 18568158
PROVIDER: scopus
PMCID: PMC2587208
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: CSRVB" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Derek S Tan
    68 Tan
  2. Justin Scott Cisar
    5 Cisar