Cheminformatic comparison of approved drugs from natural product versus synthetic origins Journal Article
| Authors: | Stratton, C. F.; Newman, D. J.; Tan, D. S. |
| Article Title: | Cheminformatic comparison of approved drugs from natural product versus synthetic origins |
| Abstract: | Despite the recent decline of natural product discovery programs in the pharmaceutical industry, approximately half of all new drug approvals still trace their structural origins to a natural product. Herein, we use principal component analysis to compare the structural and physicochemical features of drugs from natural product-based versus completely synthetic origins that were approved between 1981 and 2010. Drugs based on natural product structures display greater chemical diversity and occupy larger regions of chemical space than drugs from completely synthetic origins. Notably, synthetic drugs based on natural product pharmacophores also exhibit lower hydrophobicity and greater stereochemical content than drugs from completely synthetic origins. These results illustrate that structural features found in natural products can be successfully incorporated into synthetic drugs, thereby increasing the chemical diversity available for small-molecule drug discovery. © 2015 Elsevier Ltd. All rights reserved. |
| Keywords: | drug approval; drug structure; pharmacophore; natural product; physical chemistry; natural products; drug; principal component analysis; hydrophobicity; cheminformatics; physicochemical properties; article; synthetic drugs |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 25 |
| Issue: | 21 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2015-11-01 |
| Start Page: | 4802 |
| End Page: | 4807 |
| Language: | English |
| DOI: | 10.1016/j.bmcl.2015.07.014 |
| PROVIDER: | scopus |
| PMCID: | PMC4607632 |
| PUBMED: | 26254944 |
| DOI/URL: | |
| Notes: | Export Date: 2 November 2015 -- Source: Scopus |
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