Current progress in natural product-like libraries for discovery screening Journal Article
| Author: | Tan, D. S. |
| Article Title: | Current progress in natural product-like libraries for discovery screening |
| Abstract: | Natural product-like libraries represent an effort to combine the attractive features of natural products and combinatorial libraries for high-throughput screening. Three approaches to natural product-like library design are discussed: (1) Libraries based on core scaffolds from individual natural products, (2) libraries of diverse structures with general structural characteristics of natural products, and (3) libraries of diverse structures based on specific structural motifs from classes of natural products. Examples of successful applications in discovery screening are described for each category. These studies highlight the exciting potential of natural product-like libraries in both chemical biology and drug discovery. |
| Keywords: | unclassified drug; histone deacetylase inhibitor; genetic analysis; cell proliferation; phenotype; apoptosis; protein protein interaction; cell differentiation; drug potency; high throughput screening; drug screening; drug discovery; drug evaluation, preclinical; drug design; drug selectivity; structure activity relation; vasculotropin inhibitor; vasculotropin receptor 2; enzyme linked immunosorbent assay; gene interaction; prostaglandin e2; reporter gene; quinone derivative; virus replication; staphylococcus aureus; methicillin resistant staphylococcus aureus; natural product; ic 50; structure analysis; databases, factual; cytomegalovirus; diels alder reaction; deacetylation; angiopoietin 2; combinatorial chemistry; combinatorial chemistry techniques; tubacin; biological factors; ceramide; diversity-oriented synthesis; high-throughput screening; drug identification; enantioselectivity; human cytomegalovirus; chemical biology; cholinesterase inhibitor; staphylococcus; betulaceae; sphingosine derivative; human herpesvirus 5; 1,3 dioxane derivative; dysidiolide; galantamine; mepyramine maleate; human; priority journal; article; indolactam v; quantitative structure-activity relationship |
| Journal Title: | Combinatorial Chemistry and High Throughput Screening |
| Volume: | 7 |
| Issue: | 7 |
| ISSN: | 1386-2073 |
| Publisher: | Bentham Science Publishers |
| Date Published: | 2004-11-01 |
| Start Page: | 631 |
| End Page: | 643 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15578925 |
| DOI: | 10.2174/1386207043328418 |
| DOI/URL: | |
| Notes: | Comb. Chem. High Throughput Screen. -- Cited By (since 1996):39 -- Export Date: 16 June 2014 -- CODEN: CCHSF C2 - 15578925 -- Source: Scopus |
