Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries Journal Article
| Authors: | Shang, S.; Tan, D. S. |
| Article Title: | Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries |
| Abstract: | Natural products provide the inspiration for a variety of strategies used in the diversity-oriented synthesis of novel small-molecule libraries. These libraries can be based on core scaffolds from individual natural products, specific substructures found across a class of natural products, or general structural characteristics of natural products. An increasing body of evidence supports the effectiveness of these strategies for identifying new biologically active molecules. Moreover, these efforts have led to significant advances in synthetic organic chemistry. Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | unclassified drug; histone deacetylase inhibitor; review; nonhuman; protein conformation; biology; drug structure; molecular library; drug design; structure activity relation; data base; databases, protein; antiinfective agent; chemistry; molecular structure; vancomycin; natural product; synthesis; protein inhibitor; combinatorial chemistry techniques; tubacin; biological factors; organic chemistry; receptor blocking agent; cholinesterase inhibitor; gelatinase inhibitor; 1,3 dioxane derivative; benzopyran derivative; dysidiolide; fexachloramide; galantamine; mepyramine maleate; secramine; spirotryprostatin b; stilbene derivative; tsri 265; ureptupamine b |
| Journal Title: | Current Opinion in Chemical Biology |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1367-5931 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-06-01 |
| Start Page: | 248 |
| End Page: | 258 |
| Language: | English |
| DOI: | 10.1016/j.cbpa.2005.03.006 |
| PUBMED: | 15939326 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 76" - "Export Date: 24 October 2012" - "CODEN: COCBF" - "Source: Scopus" |
