Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective Journal Article
| Authors: | Bauer, R. A.; Wurst, J. M.; Tan, D. S. |
| Article Title: | Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective |
| Abstract: | Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein-protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets. © 2010 Elsevier Ltd. All rights reserved. |
| Keywords: | unclassified drug; dna-binding proteins; clinical trial; drug activity; review; nonhuman; drug targeting; antineoplastic agent; dna synthesis; animals; dna repair; protein protein interaction; antineoplastic activity; drug structure; drug discovery; molecular library; small molecule libraries; high-throughput screening assays; drug delivery systems; structure analysis; protein interaction mapping; molecular probe; drug protein binding; physical chemistry; protein dna interaction; nucleic acid; abyssomicin c; avrainvillamide; e 7107; fr 901464; gemmacin; lactam carboxamide; pladienolide b; rabotnikinin; antibacterial activity; antiproliferative activity |
| Journal Title: | Current Opinion in Chemical Biology |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1367-5931 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-06-01 |
| Start Page: | 308 |
| End Page: | 314 |
| Language: | English |
| DOI: | 10.1016/j.cbpa.2010.02.001 |
| PUBMED: | 20202892 |
| PROVIDER: | scopus |
| PMCID: | PMC2878877 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: COCBF" - "Source: Scopus" |
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