Diversity-oriented synthesis: Exploring the intersections between chemistry and biology Journal Article
| Author: | Tan, D. S. |
| Article Title: | Diversity-oriented synthesis: Exploring the intersections between chemistry and biology |
| Abstract: | Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of combinatorial libraries of diverse small molecules for biological screening. Rather than being directed toward a single biological target, DOS libraries can be used to identify new ligands for a variety of targets. Several different strategies for library design have been developed to target the biologically relevant regions of chemical structure space. DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry. |
| Keywords: | signal transduction; genetics; review; methodology; proteins; animal; metabolism; animals; biology; protein; drug effect; drug design; drug antagonism; chemistry, organic; combinatorial chemistry; combinatorial chemistry techniques; organic chemistry |
| Journal Title: | Nature Chemical Biology |
| Volume: | 1 |
| Issue: | 2 |
| ISSN: | 1552-4450 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-07-01 |
| Start Page: | 74 |
| End Page: | 84 |
| Language: | English |
| DOI: | 10.1038/nchembio0705-74 |
| PUBMED: | 16408003 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 203" - "Export Date: 24 October 2012" - "Source: Scopus" |
