Small molecule natural products in the discovery of therapeutic agents: The synthesis connection Journal Article

  


Authors: Wilson, R. M.; Danishefsky, S. J.
Article Title: Small molecule natural products in the discovery of therapeutic agents: The synthesis connection
Abstract: Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself. © 2006 American Chemical Society.
Keywords: unclassified drug; review; paclitaxel; unindexed drug; drug structure; drug design; drug synthesis; docetaxel; esterification; molecular structure; morphine; trabectedin; drug therapy; natural product; cantharidin; atorvastatin; simvastatin; rapamycin; synthesis (chemical); ring closing metathesis; product development; ixabepilone; epothilone b; epothilone d; biological factors; biotin; chemical modification; estrone; equilenin; organic chemicals; derivatives; natural products; mevinolin; pravastatin; streptomycin; progesterone; halichondrin b; drug products; kos 1584; cocaine; prostaglandin f2 alpha; reserpine; strychnine; international trade; pharmaceutical imports; therapeutic agents; aconitine; ajmaline; compactin; disodium hydrogen phosphate; e 7389; endiandric acid a; gibberellic acid; ginkgolide b; indolizomycin; kos 1591; longifolene; lycopodine; penicillin v; phomoidride b; quinine; tsukubaenolide
Journal Title: Journal of Organic Chemistry
Volume: 71
Issue: 22
ISSN: 0022-3263
Publisher: American Chemical Society  
Date Published: 2006-10-27
Start Page: 8329
End Page: 8351
Language: English
DOI: 10.1021/jo0610053
PUBMED: 17064003
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33750464876&partnerID=40&md5=9d2bd2197394b8527e354d9c36f80e88
Notes: --- - "Cited By (since 1996): 137" - "Export Date: 4 June 2012" - "CODEN: JOCEA" - "Source: Scopus"
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Rebecca Wilson
    17 Wilson
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