Brain tumor stem cells Journal Article
| Authors: | Panagiotakos, G.; Tabar, V. |
| Article Title: | Brain tumor stem cells |
| Abstract: | The concept of brain tumor stem cells is gaining increased recognition in neuro-oncology. Until recently, the paradigm of a tumor-initiating stem cell was confined to hematopoietic malignancies where the hierarchical lineages of stem progenitor cells are well established. The demonstration of persistent stem cells and cycling progenitors in the adult brain, coupled with the expansion of the cancer stem cell concept to solid tumors, has led to the exploration of "stemness" within gliomas. Emerging data are highly suggestive of the subsistence of transformed multipotential cells within a glioma, with a subfraction of cells exhibiting increased efficiency at tumor initiation. However, data in support of true glioma stem cells are inconclusive to date, particularly with respect to functional characterization of these cells. Ongoing work aims at the identification of unique pathways governing self-renewal of these putative stem cells and at their validation as ultimate therapeutic targets, Copyright © 2007 by Current Medicine Group LLC. |
| Keywords: | signal transduction; review; nonhuman; solid tumor; brain tumor; glioma; brain neoplasms; mitosis; phenotype; animals; somatic cell; astrocyte; cell differentiation; carcinogenesis; cell transformation, neoplastic; disease model; hematologic malignancy; glioblastoma; medulloblastoma; cancer stem cell; cyclopamine; nervous system development; tumor stem cells |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2007-05-01 |
| Start Page: | 215 |
| End Page: | 220 |
| Language: | English |
| DOI: | 10.1007/s11910-007-0033-3 |
| PUBMED: | 17488587 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: CNNRB" - "Source: Scopus" |
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