Evidence for and against regional differences in neural stem and progenitor cells of the CNS Journal Article
| Authors: | Becher, O. J.; Holland, E. C. |
| Article Title: | Evidence for and against regional differences in neural stem and progenitor cells of the CNS |
| Abstract: | Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues (pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain. © 2010 by Cold Spring Harbor Laboratory Press. |
| Keywords: | epidermal growth factor; review; nonhuman; glioma; cell proliferation; animals; mice; mice, knockout; cells, cultured; cell function; cell maturation; protein depletion; brain cortex; genetic variability; cell renewal; neural stem cell; cell differentiation; neurons; phosphorylation; central nervous system; stem cell; fibroblast growth factor 2; brain; brain development; proto-oncogene proteins c-akt; glia cell; neuroglia; stem cells; neurofibromin; neurofibromin 1; somatomedin c; akt; cerebral cortex; nerve cell differentiation; neurogenesis; brain stem; brain region; mtor; cell transplantation; perinatal period; gliogenesis; regional heterogeneity |
| Journal Title: | Genes and Development |
| Volume: | 24 |
| Issue: | 20 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2010-10-15 |
| Start Page: | 2233 |
| End Page: | 2238 |
| Language: | English |
| DOI: | 10.1101/gad.1988010 |
| PUBMED: | 20952533 |
| PROVIDER: | scopus |
| PMCID: | PMC2956202 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: GEDEE" - "Source: Scopus" |
