Human ESC-derived neural rosettes and neural stem cell progression Conference Paper
| Authors: | Elkabetz, Y.; Studer, L. |
| Title: | Human ESC-derived neural rosettes and neural stem cell progression |
| Conference Title: | 73rd Cold Spring Harbor Symposium on Quantitative Biology |
| Abstract: | Neural stem cells (NSCs) are defined by their ability to self-renew while retaining differentiation potential toward the three main central nervous system (CNS) lineages: neurons, astrocytes, and oligodendrocytes. A less appreciated fact about isolated NSCs is their narrow repertoire for generating specific neuron types, which are generally limited to a few region-specific subtypes such as GABAergic and glutamatergic neurons. Recent studies in human embryonic stem cells have identified a novel neural stem cell stage at which cells exhibit plasticity toward generating a broad range of neuron types in response to appropriate developmental signals. Such rosette-stage NSCs (R-NSCs) are also distinct from other NSC populations by their specific cytoarchitecture, gene expression, and extrinsic growth requirements. Here, we discuss the properties of R-NSCs within the context of NSC biology and define some of the key questions for future investigation. R-NSCs may represent the first example of a NSC population capable of recreating the full cellular diversity of the developing CNS, with implications for both basic stem cell biology and translational applications in regenerative medicine and drug discovery. ©2008 Cold Spring Harbor Laboratory Press. |
| Keywords: | review; conference paper; cell proliferation; cytology; metabolism; cells, cultured; cell function; cell structure; biological model; cell growth; cell maturation; embryonic stem cell; cell renewal; neural stem cell; cell differentiation; neurons; cell population; gene expression regulation; gene expression regulation, developmental; membrane antigen; cell culture; embryonic stem cells; cell aggregation; rosette formation; nervous system development; neurogenesis; nerve cell; antigens, surface; models, neurological; antigen forse 1; antigen forse-1 |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 73 |
| Conference Dates: | 2008 May 28-Jun 3 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2008-01-01 |
| Start Page: | 377 |
| End Page: | 387 |
| Language: | English |
| DOI: | 10.1101/sqb.2008.73.052 |
| PUBMED: | 19204067 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: CSHSA" - "Source: Scopus" |
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