Radiation resistance and stem-like cells in brain tumors Journal Article
| Authors: | Hambardzumyan, D.; Squartro, M.; Holland, E. C. |
| Article Title: | Radiation resistance and stem-like cells in brain tumors |
| Abstract: | The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | nonhuman; cancer radiotherapy; radiation dose; brain tumor; brain neoplasms; dna damage; cancer cell culture; glioma cell; glioblastoma; cancer stem cell; peptides; short survey; radiosensitivity; checkpoint kinase 2; cd133 antigen; antigens, cd; checkpoint kinase 1; cell cycle regulation; glycoproteins; radiobiology; radiation tolerance; in vivo culture; tumor stem cells |
| Journal Title: | Cancer Cell |
| Volume: | 10 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2006-12-01 |
| Start Page: | 454 |
| End Page: | 456 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2006.11.008 |
| PUBMED: | 17157785 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 61" - "Export Date: 4 June 2012" - "CODEN: CCAEC" - "Source: Scopus" |
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