Definition of selectable cell surface markers for human chromosomes and chromosome segments in rodent-human hybrids Journal Article

  


Authors: Rettig, W. J.; Grzeschik, K. H.; Yenamandra, A. K.; Garcia, E.; Old, L. J.
Article Title: Definition of selectable cell surface markers for human chromosomes and chromosome segments in rodent-human hybrids
Abstract: A panel of 22 monoclonal antibodies (MAbs) recognizing 21 distinct human cell surface antigens was tested by mixed hemadsorption assays for reactivity with a large number of rodent-human somatic cell hybrids containing different subsets of the human chromosome complement. The serological typing results permit the assignment of six gene loci determining cell surface antigens to human chromosomes 3, 6, 11, 19, 20, and 22. In addition, analysis of hybrids retaining deleted copies (but no normal homologs) of specific human chromosomes provides regional assignments for 18 gene loci, located on seven different chromosomes. These findings extend and refine the genetic map for human cell surface antigens and identify new selectable markers for defined chromosome segments. © 1988 Plenum Publishing Corporation.
Keywords: human cell; nonhuman; animal cell; chromosome 19; mouse; animal; cytology; mice; heredity; tumor cells, cultured; monoclonal antibody; gene mapping; membrane antigen; antibodies, monoclonal; cell culture; chromosome 11; chromosome 6; genetic markers; gene location; normal human; antigens, surface; chromosome mapping; chromosome 3; chromosome 22; chromosome 20; hybrid cell; hybrid cells; normal value; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hamsters; gene assignment
Journal Title: Somatic Cell and Molecular Genetics
Volume: 14
Issue: 3
ISSN: 0740-7750
Publisher: Springer New York LLC  
Date Published: 1988-05-01
Start Page: 223
End Page: 231
Language: English
DOI: 10.1007/bf01534583
PUBMED: 3163425
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023897091&doi=10.1007%2fBF01534583&partnerID=40&md5=f3aa90152431e5b50961d04af5ee2bde
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Lloyd J Old
    593 Old
  2. Wolfgang J. Rettig
    85 Rettig
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