Mls and the helper T‐cell repertoire: I. Mls as a regulator of T‐helper cell activation Journal Article
| Authors: | Hämmerling, U.; Toulon, M.; Palfree, R. G. E.; Hoffmann, M. K. |
| Article Title: | Mls and the helper T‐cell repertoire: I. Mls as a regulator of T‐helper cell activation |
| Abstract: | We provide evidence that the Mls reaction involves a broad cross‐section of the helper cell population. In addition to those cells reacting overtly to Mls stimulatory spleen cells, there is a second large population of helper cells that are affected by an Mls difference. This latent Mls effect is manifested by either synergy or antagonism in mitogen‐mediated, Ia‐dependent T‐cell activation, depending on Mlsa or Mlsb phenotypes of stimulator cells, respectively. Our data can be explained by attributing to Mls alleles the function of differential regulation of autoreactivity of T cells. The results show that the concept of the Mls exerting a negative signal deserves serious consideration. Copyright © 1988, Wiley Blackwell. All rights reserved |
| Keywords: | nonhuman; t lymphocyte; t-lymphocytes; mouse; animal; mice; heredity; lymphocyte activation; cell culture; t-lymphocytes, helper-inducer; histocompatibility antigens class ii; antigen-presenting cells; helper cell; antigens, surface; priority journal; support, u.s. gov't, p.h.s.; minor lymphocyte stimulatory antigens; mls locus |
| Journal Title: | International Journal of Immunogenetics |
| Volume: | 15 |
| Issue: | 1-3 |
| ISSN: | 1744-3121 |
| Publisher: | Wiley-Blackwell |
| Date Published: | 1988-02-01 |
| Start Page: | 169 |
| End Page: | 174 |
| Language: | English |
| DOI: | 10.1111/j.1744-313X.1988.tb00419.x |
| PUBMED: | 2976780 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Published while under the journal's earlier title, "Journal of Immunogenetics" (ISSN: 0305-1811) -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
79Hammerling -
28Hoffmann -
17Palfree
Related MSK Work