| Abstract: |
Blocking studies carried out with anti‐H‐2 class II antigen antibodies show that H‐2 class II molecules are intimately involved in the recognition of Mlsa determinants by unprimed, specifically responsive T cells. The blocking of the anti‐Mlsa response by these antibodies was not due to inhibition of IL‐1 production by H‐2 class II antigen positive macrophages. A strain analysis indicates that the response to Mlsa is regulated by H‐2‐linked genes and that this effect is exerted at the level of the stimulator cells; however, the response to Mls epitopes does not appear to be H‐2 restricted. Finally, the ability of spleen cells from Mls‐incompatible mice to induce a state of Mls‐specific, clonal deletion type tolerance by neonatal injection, shows that Mls determinants exist in qualitatively allelic forms and suggests that these determinants are recognized by specific clones of T cells. Copyright © 1988, Wiley Blackwell. All rights reserved |
| Keywords: |
nonhuman; t-lymphocytes; mouse; animal; mice; heredity; mice, inbred strains; lymphocyte activation; immune tolerance; cell culture; major histocompatibility antigen class 2; animals, newborn; macrophage; histocompatibility antigens class ii; genes, mhc class ii; in vitro; antigens, surface; interleukin 1; epitopes; h-2 antigens; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; h2 system; minor lymphocyte stimulatory antigens; mls locus
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