Mls and the helper T‐cell repertoire: II. Does the Mls gene product influence the formation of the T‐cell repertoire? Studies with Mls tolerance Journal Article
| Authors: | Hoffmann, M. K.; Chun, M.; Dennig, D.; Hämmerling, U. |
| Article Title: | Mls and the helper T‐cell repertoire: II. Does the Mls gene product influence the formation of the T‐cell repertoire? Studies with Mls tolerance |
| Abstract: | In the formation of a repertoire, T cells are selected through a window of autoreactivity which is defined by a low boundary representing the minimal autoreactivity required to enter the T‐cell compartment and a high boundary which determines the highest admissible autoreactivity. We propose that the Mls gene product down regulates autoreactivity and thus modifies the formation of the T‐cell repertoire. Given the polymorphism of Mls and the assumption that Mlsb is more inhibitory than Mlsd, it is conceivable that Mlsb (responder) mice admit into their T‐cell compartment T cells with higher autoreactivity than Mlsd mice. We suggest that it is this highly autoreactive fraction of Mlsb T cells which responds in the overt Mls response. We show that Mls tolerance eliminates T cells responding in the overt Mls response but not T cells responding in the latent Mls response. This is consistent with the finding that T cells responding in the latent Mls response occur in Mlsb as well as in Mlsd mice. Copyright © 1988, Wiley Blackwell. All rights reserved |
| Keywords: | nonhuman; t lymphocyte; mouse; animal; mice; heredity; mice, inbred strains; immune tolerance; cell culture; autoantigens; t-lymphocytes, helper-inducer; major histocompatibility complex; antigen-presenting cells; helper cell; antigens, surface; priority journal; support, u.s. gov't, p.h.s.; minor lymphocyte stimulatory antigens; mls locus |
| Journal Title: | International Journal of Immunogenetics |
| Volume: | 15 |
| Issue: | 1-3 |
| ISSN: | 1744-3121 |
| Publisher: | Wiley-Blackwell |
| Date Published: | 1988-02-01 |
| Start Page: | 175 |
| End Page: | 181 |
| Language: | English |
| DOI: | 10.1111/j.1744-313X.1988.tb00420.x |
| PUBMED: | 2976781 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Published while under the journal's earlier title, "Journal of Immunogenetics" (ISSN: 0305-1811) -- Source: Scopus |
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28Hoffmann
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