Hyperpolarized MRI of human prostate cancer reveals increased lactate with tumor grade driven by monocarboxylate transporter 1 Journal Article
| Authors: | Granlund, K. L.; Tee, S. S.; Vargas, H. A.; Lyashchenko, S. K.; Reznik, E.; Fine, S.; Laudone, V.; Eastham, J. A.; Touijer, K. A.; Reuter, V. E.; Gonen, M.; Sosa, R. E.; Nicholson, D.; Guo, Y. W.; Chen, A. P.; Tropp, J.; Robb, F.; Hricak, H.; Keshari, K. R. |
| Article Title: | Hyperpolarized MRI of human prostate cancer reveals increased lactate with tumor grade driven by monocarboxylate transporter 1 |
| Abstract: | Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of primary prostate cancer. We show that the time to max of pyruvate does not vary significantly within patients undergoing two separate injections or across patients. Furthermore, we show that lactate increases with Gleason grade. RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1. Increased protein expression was also observed in regions of high lactate signal, implicating it as the driver of lactate signal in vivo. Targeted DNA sequencing for actionable mutations revealed the highest lactate occurred in patients with PTEN loss. This work identifies a potential link between actionable genomic alterations and metabolic information derived from hyperpolarized pyruvate MRI. Copyright © 2019 Elsevier Inc. All rights reserved. |
| Keywords: | metabolic imaging; glycolytic flux; hyperpolarized pyruvate; in vivo kinetics |
| Journal Title: | Cell Metabolism |
| Volume: | 31 |
| Issue: | 1 |
| ISSN: | 1550-4131 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-01-07 |
| Start Page: | 105 |
| End Page: | 114.e3 |
| Language: | English |
| DOI: | 10.1016/j.cmet.2019.08.024 |
| PUBMED: | 31564440 |
| PROVIDER: | scopus |
| PMCID: | PMC6949382 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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