Task activation results in regional (13)C-lactate signal increase in the human brain Journal Article
| Authors: | Uthayakumar, B.; Cappelletto, N. I. C.; Bragagnolo, N. D.; Chen, A. P.; Ma, N.; Perks, W. J.; Endre, R.; Tam, F.; Graham, S. J.; Heyn, C.; Keshari, K. R.; Soliman, H.; Cunningham, C. H. |
| Article Title: | Task activation results in regional (13)C-lactate signal increase in the human brain |
| Abstract: | Hyperpolarized-13C magnetic resonance imaging (HP-13C MRI) was used to image changes in 13C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain 13C-pyruvate, 13C-lactate and 13C-bicarbonate production was imaged in healthy volunteers (N = 6, ages 24–33) for the two conditions using two separate hyperpolarized 13C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation. 13C-metabolite signal was normalized by 13C-metabolite signal from the brainstem and the percentage change in 13C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in 13C-lactate in regions of activation when compared to the remainder of the brain ((Formula presented.)). No significant increase was observed in 13C-pyruvate signal ((Formula presented.)) or 13C-bicarbonate signal ((Formula presented.)). The results show an increase in 13C-lactate production in activated regions that is measurable with HP-13C MRI. © The Author(s) 2025. |
| Keywords: | molecular imaging; energy metabolism; mri; lactate; mr metabolite |
| Journal Title: | Journal of Cerebral Blood Flow and Metabolism |
| ISSN: | 0271-678X |
| Publisher: | Sage Publications Ltd. |
| Publication status: | Online ahead of print |
| Date Published: | 2025-07-01 |
| Online Publication Date: | 2025-07-01 |
| Language: | English |
| DOI: | 10.1177/0271678x251314683 |
| PROVIDER: | scopus |
| PMCID: | PMC11765303 |
| PUBMED: | 39862181 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Source: Scopus |
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