Metabolic imaging of the human brain with hyperpolarized (13)C pyruvate demonstrates (13)C lactate production in brain tumor patients Journal Article

   

Authors:	Miloushev, V. Z.; Granlund, K. L.; Boltyanskiy, R.; Lyashchenko, S. K.; DeAngelis, L. M.; Mellinghoff, I. K.; Brennan, C. W.; Tabar, V.; Yang, T. J.; Holodny, A. I.; Sosa, R. E.; Guo, Y. W.; Chen, A. P.; Tropp, J.; Robb, F.; Keshari, K. R.
Article Title:	Metabolic imaging of the human brain with hyperpolarized (13)C pyruvate demonstrates (13)C lactate production in brain tumor patients
Abstract:	Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. In vivo production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, whereas production of HP lactate in the entire brain was likely due to baseline metabolism. We correlated our results with standard clinical brain MRI, MRI DCE perfusion, and in one case FDG PET/ CT. Our results suggest that HP 13C pyruvate-to-lactate conversion may be a viable metabolic biomarker for assessing tumor response. Significance: Hyperpolarized pyruvate MRI enables metabolic imaging in the brain and can be a quantitative biomarker for active tumors. ©2018 American Association for Cancer Research.
Journal Title:	Cancer Research
Volume:	78
Issue:	14
ISSN:	0008-5472
Publisher:	American Association for Cancer Research
Date Published:	2018-07-01
Start Page:	3755
End Page:	3760
Language:	English
DOI:	10.1158/0008-5472.can-18-0221
PROVIDER:	scopus
PMCID:	PMC6050093
PUBMED:	29769199
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050662987&doi=10.1158%2f0008-5472.CAN-18-0221&partnerID=40&md5=3405718a5939e99548b62c7b482f7b68
Notes:	Article -- Export Date: 4 September 2018 -- Source: Scopus