Hyperpolarized (13)C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T Journal Article

Authors: Miloushev, V. Z.; Di Gialleonardo, V.; Salamanca-Cardona, L.; Correa, F.; Granlund, K. L.; Keshari, K. R.
Article Title: Hyperpolarized (13)C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T
Abstract: The expected signal in echo-planar spectroscopic imaging experiments was explicitly modeled jointly in spatial and spectral dimensions. Using this as a basis, absorptive-mode type detection can be achieved by appropriate choice of spectral delays and post-processing techniques. We discuss the effects of gradient imperfections and demonstrate the implementation of this sequence at low field (1.05 T), with application to hyperpolarized [1-13C] pyruvate imaging of the mouse brain. The sequence achieves sufficient signal-to-noise to monitor the conversion of hyperpolarized [1-13C] pyruvate to lactate in the mouse brain. Hyperpolarized pyruvate imaging of mouse brain metabolism using an absorptive-mode EPSI sequence can be applied to more sophisticated murine disease and treatment models. The simple modifications presented in this work, which permit absorptive-mode detection, are directly translatable to human clinical imaging and generate improved absorptive-mode spectra without the need for refocusing pulses. © 2016 Elsevier Inc.
Keywords: metabolism; physiology; medical imaging; spin polarization; mammals; signal to noise ratio; hyperpolarized mri; hyperpolarized; pyruvates; absorptive mode; epsi; mouse brain; [1-13c] pyruvate
Journal Title: Journal of Magnetic Resonance
Volume: 275
ISSN: 1090-7807
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2017-02-01
Start Page: 120
End Page: 126
Language: English
DOI: 10.1016/j.jmr.2016.12.009
PROVIDER: scopus
PUBMED: 28061381
PMCID: PMC5554620
Notes: Article -- Export Date: 2 February 2017 -- Source: Scopus
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