Hyperpolarized (13)C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T Journal Article
| Authors: | Miloushev, V. Z.; Di Gialleonardo, V.; Salamanca-Cardona, L.; Correa, F.; Granlund, K. L.; Keshari, K. R. |
| Article Title: | Hyperpolarized (13)C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T |
| Abstract: | The expected signal in echo-planar spectroscopic imaging experiments was explicitly modeled jointly in spatial and spectral dimensions. Using this as a basis, absorptive-mode type detection can be achieved by appropriate choice of spectral delays and post-processing techniques. We discuss the effects of gradient imperfections and demonstrate the implementation of this sequence at low field (1.05 T), with application to hyperpolarized [1-13C] pyruvate imaging of the mouse brain. The sequence achieves sufficient signal-to-noise to monitor the conversion of hyperpolarized [1-13C] pyruvate to lactate in the mouse brain. Hyperpolarized pyruvate imaging of mouse brain metabolism using an absorptive-mode EPSI sequence can be applied to more sophisticated murine disease and treatment models. The simple modifications presented in this work, which permit absorptive-mode detection, are directly translatable to human clinical imaging and generate improved absorptive-mode spectra without the need for refocusing pulses. © 2016 Elsevier Inc. |
| Keywords: | metabolism; physiology; medical imaging; spin polarization; mammals; signal to noise ratio; hyperpolarized mri; hyperpolarized; pyruvates; absorptive mode; epsi; mouse brain; [1-13c] pyruvate |
| Journal Title: | Journal of Magnetic Resonance |
| Volume: | 275 |
| ISSN: | 1090-7807 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2017-02-01 |
| Start Page: | 120 |
| End Page: | 126 |
| Language: | English |
| DOI: | 10.1016/j.jmr.2016.12.009 |
| PROVIDER: | scopus |
| PUBMED: | 28061381 |
| PMCID: | PMC5554620 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 February 2017 -- Source: Scopus |
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