Evidence of (13)C-lactate oxidation in the human brain from hyperpolarized (13)C-MRI Journal Article
| Authors: | Uthayakumar, B.; Soliman, H.; Chen, A. P.; Bragagnolo, N.; Cappelletto, N. I. C.; Endre, R.; Perks, W. J.; Ma, N.; Heyn, C.; Keshari, K. R.; Cunningham, C. H. |
| Article Title: | Evidence of (13)C-lactate oxidation in the human brain from hyperpolarized (13)C-MRI |
| Abstract: | Purpose: To test the hypothesis that lactate oxidation contributes to the (Formula presented.) C-bicarbonate signal observed in the awake human brain using hyperpolarized (Formula presented.) C MRI. Methods: Healthy human volunteers (N = 6) were scanned twice using hyperpolarized (Formula presented.) C-MRI, with increased radiofrequency saturation of (Formula presented.) C-lactate on one set of scans. (Formula presented.) C-lactate, (Formula presented.) C-bicarbonate, and (Formula presented.) C-pyruvate signals for 132 brain regions across each set of scans were compared using a clustered Wilcoxon signed-rank test. Results: Increased (Formula presented.) C-lactate radiofrequency saturation resulted in a significantly lower (Formula presented.) C-bicarbonate signal (p = 0.04). These changes were observed across the majority of brain regions. Conclusion: Radiofrequency saturation of (Formula presented.) C-lactate leads to a decrease in (Formula presented.) C-bicarbonate signal, demonstrating that the (Formula presented.) C-lactate generated from the injected (Formula presented.) C-pyruvate is being converted back to (Formula presented.) C-pyruvate and oxidized throughout the human brain. © 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. |
| Keywords: | adult; middle aged; nuclear magnetic resonance imaging; magnetic resonance imaging; diagnostic imaging; correlation analysis; brain; magnetic resonance; cognitive defect; biochemistry; oxidation; brain region; radiofrequency; polarization; normal human; digital imaging and communications in medicine; human experiment; carbon; carbon isotopes; carbon nuclear magnetic resonance; lactic acid; human brain; pyruvic acid; normal; carbon 13; false discovery rate; procedures; bicarbonate; wilcoxon signed ranks test; neurological; hyperpolarized; wilcoxon signed rank test; humans; human; article; brain regions; pyruvates; bicarbonates; montreal cognitive assessment; t1 weighted imaging; healthy humans; human volunteers; radiofrequencies |
| Journal Title: | Magnetic Resonance in Medicine |
| Volume: | 91 |
| Issue: | 5 |
| ISSN: | 0740-3194 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-05-01 |
| Start Page: | 2162 |
| End Page: | 2171 |
| Language: | English |
| DOI: | 10.1002/mrm.29919 |
| PUBMED: | 38230992 |
| PROVIDER: | scopus |
| PMCID: | PMC11225103 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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