Monocyte recruitment during infection and inflammation Journal Article
| Authors: | Shi, C.; Pamer, E. G. |
| Article Title: | Monocyte recruitment during infection and inflammation |
| Abstract: | Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, pro-inflammatory cytokines and microbial products, they differentiate into macrophage or dendritic cell populations. Recruitment of monocytes is essential for effective control and clearance of viral, bacterial, fungal and protozoal infections, but recruited monocytes also contribute to the pathogenesis of inflammatory and degenerative diseases. The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review. © 2011 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | protein expression; review; hepatitis; nonhuman; unindexed drug; infection; bone marrow; vascular cell adhesion molecule 1; inflammation; trypanosoma brucei; cd16 antigen; th2 cell; mycobacterium tuberculosis; gamma interferon; atherosclerosis; cd11b antigen; cd4+ t lymphocyte; cell subpopulation; vaccinia virus; natural killer cell; polyinosinic polycytidylic acid; cytokine production; th1 cell; monocyte; infection prevention; monocyte chemotactic protein 3; homeostasis; chemokine receptor ccr7; cytomegalovirus infection; intercellular adhesion molecule 1; cytomegalovirus; myeloid differentiation factor 88; aspergillus fumigatus; chemokine receptor ccr2; aspergillosis; monocyte chemotactic protein 1; listeriosis; listeria monocytogenes; cd14 antigen; tuberculosis; west nile flavivirus; endothelial leukocyte adhesion molecule 1; tumor necrosis factor; cd31 antigen; inducible nitric oxide synthase; monocyte chemotactic protein 5; allergic encephalomyelitis; leukocyte migration; toxoplasmosis; p selectin glycoprotein ligand 1; l selectin; chemokine receptor ccr5; monocyte chemotactic protein 2; peritonitis; lymphocyte function associated antigen 1; very late activation antigen 4; blastomyces dermatitidis; blastomycosis; african trypanosomiasis; chemokine receptor ccr6; macrophage inflammatory protein 1alpha; leishmania major; toxoplasma gondii; cryptococcosis; cryptococcus neoformans; chemokine receptor ccr1; chemokine receptor ccr8; chemokine receptor cx3cr1; chemokine receptor cxcr2; brucella melitensis; brucellosis; granulocytosis; leishmaniasis; leukocyte adherence; plasmodium chabaudi; plasmodium chabaudi infection; salmonella enterica; typhoid fever |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 11 |
| Issue: | 11 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-10-10 |
| Start Page: | 762 |
| End Page: | 774 |
| Language: | English |
| DOI: | 10.1038/nri3070 |
| PROVIDER: | scopus |
| PUBMED: | 21984070 |
| PMCID: | PMC3947780 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 9 December 2011" - "CODEN: NRIAB" - "Source: Scopus" |
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