Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands Journal Article

   

Authors:	Shi, C.; Jia, T.; Mendez-Ferrer, S.; Hohl, T.; Serbina, N.; Lipuma, L.; Leiner, I.; Li, M.; Frenette, P.; Pamer, E.
Article Title:	Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Abstract:	Inflammatory (Ly6Chi CCR2+) monocytes provide defense against infections but also contribute to autoimmune diseases and atherosclerosis. Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic protein-1 (MCP1). How monocyte emigration from bone marrow is triggered by remote infections remains unclear. We demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow. Bone marrow mesenchymal stem cells (MSCs) and their progeny, including CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells, rapidly expressed MCP1 in response to circulating TLR ligands or bacterial infection and induced monocyte trafficking into the bloodstream. Targeted deletion of MCP1 from MSCs impaired monocyte emigration from bone marrow. Our findings suggest that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses. © 2011 Elsevier Inc.
Keywords:	controlled study; nonhuman; mouse; bone marrow; animal experiment; stem cell; ligand; cell migration; mesenchymal stem cell; bone marrow cell; monocyte; bloodstream infection; cell transport; bacterial infection; toll like receptor; chemokine receptor ccr2; chemokine receptor cxcr4; alpha chemokine
Journal Title:	Immunity
Volume:	34
Issue:	4
ISSN:	1074-7613
Publisher:	Cell Press
Date Published:	2011-04-22
Start Page:	590
End Page:	601
Language:	English
DOI:	10.1016/j.immuni.2011.02.016
PROVIDER:	scopus
PMCID:	PMC3081416
PUBMED:	21458307
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79954591540&partnerID=40&md5=811574724aa9eda6886a6b73200c99b7
Notes:	--- - "Cited By (since 1996): 2" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus"

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