Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 Journal Article

  

Authors:	Serbina, N. V.; Pamer, E. G.
Article Title:	Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Abstract:	Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis. However, the mechanisms controlling monocyte emigration from the bone marrow niche where they are generated remain undefined. We demonstrate here that the chemokine receptor CCR2 was required for emigration of Ly6Chi monocytes from bone marrow. Ccr2-/- mice had fewer circulating Ly6Chi monocytes and, after infection with Listeria monocytogenes, accumulated activated monocytes in bone marrow. In blood, Ccr2-/- monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues. Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6Chi monocytes in the circulation. © 2006 Nature Publishing Group.
Keywords:	signal transduction; controlled study; nonhuman; flow cytometry; animal cell; mouse; animal; cytology; metabolism; animals; mice; animal tissue; bone marrow cells; bone marrow; animal experiment; animal model; cell differentiation; immunology; bone marrow cell; monocyte; monocytes; bacterial infection; bacterial infections; cell activation; chemokine receptor ccr2; antigens, ly; bioaccumulation; listeria monocytogenes; neutrophil chemotaxis; chemotaxis, leukocyte; chemokine receptor; ly 6c antigen, mouse; ly antigen; ly-6c antigen, mouse; receptors, chemokine; leukocyte migration; circulation; frequency analysis; monocyte chemoattractant protein 1 receptor
Journal Title:	Nature Immunology
Volume:	7
Issue:	3
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Date Published:	2006-03-01
Start Page:	311
End Page:	317
Language:	English
DOI:	10.1038/ni1309
PUBMED:	16462739
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-33645902493&partnerID=40&md5=4aecd31842505a2299ec05c0e8f2b8d3
Notes:	--- - "Cited By (since 1996): 295" - "Export Date: 4 June 2012" - "CODEN: NIAMC" - "Source: Scopus"

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