Monocyte-mediated defense against microbial pathogens Journal Article
| Authors: | Serbina, N. V.; Jia, T.; Hohl, T. M.; Pamer, E. G. |
| Article Title: | Monocyte-mediated defense against microbial pathogens |
| Abstract: | Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell (DC) precursors and, in the setting of infection, also contribute directly to immune defense against microbial pathogens. In humans and mice, monocytes are divided into two major subsets that either specifically traffic into inflamed tissues or, in the absence of overt inflammation, constitutively maintain tissue macrophage/DC populations. Inflammatory monocytes respond rapidly to microbial stimuli by secreting cytokines and antimicrobial factors, express the CCR2 chemokine receptor, and traffic to sites of microbial infection in response to monocyte chemoattractant protein (MCP)-1 (CCL2) secretion. In murine models, CCR2-mediated monocyte recruitment is essential for defense against Listeria monocytogenes, Mycobacterium tuberculosis, Toxoplasma gondii, and Cryptococcus neoformans infection, implicating inflammatory monocytes in defense against bacterial, protozoal, and fungal pathogens. Recent studies indicate that inflammatory monocyte recruitment to sites of infection is complex, involving CCR2-mediated emigration of monocytes from the bone marrow into the bloodstream, followed by trafficking into infected tissues. The in vivo mechanisms that promote chemokine secretion, monocyte differentiation and trafficking, and finally monocyte-mediated microbial killing remain active and important areas of investigation. Copyright © 2008 by Annual Reviews. All rights reserved. |
| Keywords: | review; nonhuman; animals; infection; dendritic cell; inflammation; in vivo study; cell differentiation; cell population; cytokine; antiinfective agent; mycobacterium tuberculosis; immune response; antigen; chemotaxis; immunity; monocyte; monocytes; chemokine receptor ccr2; receptors, ccr2; monocyte chemotactic protein 1; listeriosis; listeria monocytogenes; chemokines; mycobacteriosis; toxoplasmosis; immunity, cellular; toxoplasma gondii; microbial pathogens; monocyte differentiation; cryptococcosis; cryptococcus neoformans; immunity, mucosal; monocyte chemoattractant proteins |
| Journal Title: | Annual Review of Immunology |
| Volume: | 26 |
| ISSN: | 0732-0582 |
| Publisher: | Annual Reviews |
| Date Published: | 2008-01-01 |
| Start Page: | 421 |
| End Page: | 452 |
| Language: | English |
| DOI: | 10.1146/annurev.immunol.26.021607.090326 |
| PUBMED: | 18303997 |
| PROVIDER: | scopus |
| PMCID: | PMC2921669 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 175" - "Export Date: 17 November 2011" - "CODEN: ARIMD" - "Source: Scopus" |
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