Metabolic regulation of cell growth and proliferation Review


Authors: Zhu, J.; Thompson, C. B.
Review Title: Metabolic regulation of cell growth and proliferation
Abstract: Cellular metabolism is at the foundation of all biological activities. The catabolic processes that support cellular bioenergetics and survival have been well studied. By contrast, how cells alter their metabolism to support anabolic biomass accumulation is less well understood. During the commitment to cell proliferation, extensive metabolic rewiring must occur in order for cells to acquire sufficient nutrients such as glucose, amino acids, lipids and nucleotides, which are necessary to support cell growth and to deal with the redox challenges that arise from the increased metabolic activity associated with anabolic processes. Defining the mechanisms of this metabolic adaptation for cell growth and proliferation is now a major focus of research. Understanding the principles that guide anabolic metabolism may ultimately enhance ways to treat diseases that involve deregulated cell growth and proliferation, such as cancer. © 2019, Springer Nature Limited.
Keywords: signal transduction; review; nonhuman; cell proliferation; cell growth; amino acid; glucose; cell stimulation; homeostasis; cell interaction; fatty acid; cell metabolism; glucose transport; fatty acid synthesis; metabolic regulation; nucleotide; tumor microenvironment; glucose utilization; amino acid synthesis; saturated fatty acid; nucleotide metabolism; nutrient limitation; oxidation reduction state; metabolic stress; purine nucleotide; nutrient uptake; ribose 5 phosphate; unsaturated fatty acid; human; priority journal; nonessential amino acid; pyrimidine nucleotide
Journal Title: Nature Reviews Molecular Cell Biology
Volume: 20
Issue: 7
ISSN: 1471-0072
Publisher: Nature Publishing Group  
Date Published: 2019-07-01
Start Page: 436
End Page: 450
Language: English
DOI: 10.1038/s41580-019-0123-5
PUBMED: 30976106
PROVIDER: scopus
PMCID: PMC6592760
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Craig Bernie Thompson
    141 Thompson
  2. Jiajun Zhu
    6 Zhu