Metabolic regulation by SIRT3: Implications for tumorigenesis Journal Article
| Authors: | Finley, L. W. S.; Haigis, M. C. |
| Article Title: | Metabolic regulation by SIRT3: Implications for tumorigenesis |
| Abstract: | Cancer cells meet their needs for energy and biomass production by consuming high levels of nutrients and rewiring metabolism to support macromolecular biosynthesis. Mitochondrial enzymes play central roles in anabolic growth, and acetylation may provide a key layer of regulation over mitochondrial metabolic pathways. As a major mitochondrial deacetylase, SIRT3 regulates the activity of enzymes to coordinate global shifts in cellular metabolism. SIRT3 promotes the function of the tricarboxylic acid (TCA) cycle and the electron transport chain and reduces oxidative stress. Loss of SIRT3 triggers oxidative damage, reactive oxygen species (ROS)-mediated signaling, and metabolic reprogramming to support proliferation and tumorigenesis. Thus, SIRT3 is an intriguing example of how nutrient-sensitive, post-translational regulation may provide integrated regulation of metabolic pathways to promote metabolic homeostasis in response to diverse nutrient signals. © 2012 Elsevier Ltd. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; cell proliferation; animals; carcinogenesis; cell transformation, neoplastic; biosynthesis; enzyme regulation; protein processing, post-translational; cancer cell; reactive oxygen species; reactive oxygen metabolite; oxidative stress; nutrient; homeostasis; hypoxia inducible factor 1alpha; mitochondrion; oxidative phosphorylation; acetylation; metabolic regulation; macromolecule; succinate dehydrogenase; citric acid cycle; glutamate dehydrogenase; cytochrome c oxidase; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); succinate dehydrogenase (ubiquinone); translation regulation; mitochondrial enzyme; energy yield; electron transport; sirtuin 3; manganese superoxide dismutase; reduced nicotinamide adenine dinucleotide phosphate; acetyl coenzyme a synthetase; hydroxymethylglutaryl coenzyme a synthase; isocitrate dehydrogenase 2; long chain acyl coenzyme a dehydrogenase; mitochondrial deacetylase; ornithine carbamoyltransferase; ubiquinol cytochrome c reductase; biomass production |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 18 |
| Issue: | 9 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-09-01 |
| Start Page: | 516 |
| End Page: | 523 |
| Language: | English |
| DOI: | 10.1016/j.molmed.2012.05.004 |
| PROVIDER: | scopus |
| PUBMED: | 22749020 |
| PMCID: | PMC4765807 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "CODEN: TMMRC" - "Source: Scopus" |
