Metabolic signatures of cancer cells and stem cells Review


Authors: Intlekofer, A. M.; Finley, L. W. S.
Review Title: Metabolic signatures of cancer cells and stem cells
Abstract: In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and catabolism of nutrients to support anabolic cell growth. Intermediates of central metabolic pathways have emerged as key players that influence cell-differentiation 'decisions', processes relevant to both oncogenesis and normal development. Consequently, how cells rewire metabolic pathways to support proliferation can have profound consequences for cellular identity. Here, we discuss the metabolic programs that support proliferation, and we explore how metabolic states are intimately entwined with the cell-fate decisions that characterize stem cells and cancer cells. By comparing the metabolism of pluripotent stem cells and cancer cells, we hope to illuminate common metabolic strategies as well as distinct metabolic features that may represent specialized adaptations to unique cellular demands.
Keywords: dna methylation; self-renewal; myeloid-leukemia; acute; oxidative-phosphorylation; energy-metabolism; alpha-ketoglutarate; acetyl-coa; hypoxia-inducible factors; amino-acid-metabolism; histone deacetylase sirt6
Journal Title: Nature Metabolism
Volume: 1
Issue: 2
ISSN: 2522-5812
Publisher: Nature Publishing Group  
Date Published: 2019-02-01
Start Page: 177
End Page: 188
Language: English
ACCESSION: WOS:000500728400003
DOI: 10.1038/s42255-019-0032-0
PROVIDER: wos
PMCID: PMC6594714
PUBMED: 31245788
Notes: Source: Wos
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  1. Lydia Whitney Stillman Finley
    32 Finley