Metabolic decisions in development and disease—A Keystone Symposia report Journal Article


Authors: Cable, J.; Pourquié, O.; Wellen, K. E.; Finley, L. W. S.; Aulehla, A.; Gould, A. P.; Teleman, A.; Tu, W. B.; Garrett, W. S.; Miguel-Aliaga, I.; Perrimon, N.; Hooper, L. V.; Walhout, A. J. M.; Wei, W.; Alexandrov, T.; Erez, A.; Ralser, M.; Rabinowitz, J. D.; Hemalatha, A.; Gutiérrez-Pérez, P.; Chandel, N. S.; Rutter, J.; Locasale, J. W.; Landoni, J. C.; Christofk, H.
Article Title: Metabolic decisions in development and disease—A Keystone Symposia report
Abstract: There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, “Metabolic Decisions in Development and Disease.” The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism. © 2021 New York Academy of Sciences.
Keywords: gene mutation; nonhuman; proteome; metabolism; gene expression; cell maturation; cell fate; drosophila; embryo development; cell differentiation; carcinogenesis; stem cell; skin; oncogene; diet; genome; development; caenorhabditis elegans; developmental disorder; adenosine triphosphatase; cell communication; mesoderm; vertebrate; lipid metabolism; metabolic disorder; mitochondrion; metabolite; lipogenesis; host cell; chronic kidney failure; protein modification; metabolic regulation; tryptophan metabolism; microrna 1; tissues; wnt signaling; mitochondrial respiration; symposium; metabolomics; histone modification; receptor cross-talk; circadian rhythm; environmental stress; oscillation; microbiome; urea cycle; epigenome; cell ph; human; article; premature aging; malignant neoplasm; metabolome; metabolic fingerprinting; microbial interaction; secretomics
Journal Title: Annals of the New York Academy of Sciences
Volume: 1506
Issue: 1
ISSN: 0077-8923
Publisher: John Wiley & Sons  
Date Published: 2021-12-01
Start Page: 55
End Page: 73
Language: English
DOI: 10.1111/nyas.14678
PUBMED: 34414571
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 February 2022 -- Source: Scopus
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  1. Lydia Whitney Stillman Finley
    32 Finley