Metabolic regulation of chromatin modifications and gene expression Journal Article

   


Authors: Schvartzman, J. M.; Thompson, C. B.; Finley, L. W. S.
Article Title: Metabolic regulation of chromatin modifications and gene expression
Abstract: Dynamic regulation of gene expression in response to changing local conditions is critical for the survival of all organisms. In metazoans, coherent regulation of gene expression programs underlies the development of functionally distinct cell lineages. The cooperation between transcription factors and the chromatin landscape enables precise control of gene expression in response to cell-intrinsic and cell-extrinsic signals. Many of the chemical modifications that decorate DNA and histones are adducts derived from intermediates of cellular metabolic pathways. In addition, several of the enzymes that can remove these marks use metabolites as part of their enzymatic reaction. These observations have led to the hypothesis that fluctuations in metabolite levels influence the deposition and removal of chromatin modifications. In this review, we consider the emerging evidence that cellular metabolic activity contributes to gene expression and cell fate decisions through metabolite-dependent effects on chromatin organization.
Keywords: embryonic stem-cells; rna-polymerase-ii; acute myeloid-leukemia; pyruvate-dehydrogenase complex; bromodomain; histone acetylation; alpha-ketoglutarate; protein brd4; dna demethylation; one-carbon metabolism; cellular-metabolism
Journal Title: Journal of Cell Biology
Volume: 217
Issue: 7
ISSN: 0021-9525
Publisher: Rockefeller University Press  
Date Published: 2018-07-02
Start Page: 2247
End Page: 2259
Language: English
ACCESSION: WOS:000438081900006
DOI: 10.1083/jcb.201803061
PROVIDER: wos
PMCID: PMC6028552
PUBMED: 29760106
Notes: Review -- Source: Wos
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MSK Authors
  1. Juan M Schvartzman
    11 Schvartzman
  2. Lydia Whitney Stillman Finley
    45 Finley
  3. Craig Bernie Thompson
    153 Thompson
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