Non-enzymatic covalent modifications: A new link between metabolism and epigenetics Review


Authors: Zheng, Q.; Maksimovic, I.; Upad, A.; David, Y.
Review Title: Non-enzymatic covalent modifications: A new link between metabolism and epigenetics
Abstract: Epigenetic modifications, including those on DNA and histones, have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic pathways. In turn, metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin modifications. Recently, non-enzymatic covalent modifications (NECMs) by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple mechanisms. Here, we summarize these recent advances in the identification and characterization of NECMs on nucleic acids, histones, and transcription factors, providing an additional mechanistic link between metabolism and epigenetics. © 2020, The Author(s).
Keywords: metabolism; epigenetics; chromatin; human disease; non-enzymatic modification
Journal Title: Protein & Cell
Volume: 11
Issue: 6
ISSN: 1674-800X
Publisher: Higher Education Press  
Date Published: 2020-06-01
Start Page: 401
End Page: 416
Language: English
DOI: 10.1007/s13238-020-00722-w
PUBMED: 32356279
PROVIDER: scopus
PMCID: PMC7251012
DOI/URL:
Notes: Review -- Export Date: 1 July 2020 -- Source: Scopus
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MSK Authors
  1. Qingfei Zheng
    8 Zheng
  2. Akhil Upad
    2 Upad
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