A chemical field guide to histone nonenzymatic modifications Review

Authors: Faulkner, S.; Maksimovic, I.; David, Y.
Review Title: A chemical field guide to histone nonenzymatic modifications
Abstract: Histone nonenzymatic covalent modifications (NECMs) have recently emerged as an understudied class of posttranslational modifications that regulate chromatin structure and function. These NECMs alter the surface topology of histone proteins, their interactions with DNA and chromatin regulators, as well as compete for modification sites with enzymatic posttranslational modifications. NECM formation depends on the chemical compatibility between a reactive molecule and its target site, in addition to their relative stoichiometries. Here we survey the chemical reactions and conditions that govern the addition of NECMs onto histones as a manual to guide the identification of new physiologically relevant chemical adducts. Characterizing NECMs on chromatin is critical to attain a comprehensive understanding of this new chapter of the so-called “histone code”. © 2021 Elsevier Ltd
Keywords: epigenetics; histone; antioxidant; nucleosome; acylation; post-translational modification; lipidation; glycation; non-enzymatic covalent modifications
Journal Title: Current Opinion in Chemical Biology
Volume: 63
ISSN: 1367-5931
Publisher: Elsevier Inc.  
Date Published: 2021-08-01
Start Page: 180
End Page: 187
Language: English
DOI: 10.1016/j.cbpa.2021.05.002
PUBMED: 34157651
PROVIDER: scopus
Notes: Review -- Export Date: 2 August 2021 -- Source: Scopus
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