Signaling in control of cell growth and metabolism Journal Article


Authors: Ward, P. S.; Thompson, C. B.
Article Title: Signaling in control of cell growth and metabolism
Abstract: Mammalian cells require growth-factor-receptor-initiated signaling to proliferate. Signal transduction not only initiates entry into the cell cycle, but also reprograms cellular metabolism. This instructional metabolic reprogramming is critical if the cell is to fulfill the anabolic and energetic requirements that accompany cell growth and division. Growth factor signaling mediated by the PI3K/Akt pathway plays a major role in regulating the cellular uptake of glucose, aswell as the incorporation of this glucose carbon into lipids for membrane synthesis. Tyrosine-kinase-based regulation of key glycolytic enzymes such as pyruvate kinase also plays a critical role directing glucose carbon into anabolic pathways. In addition, the Myc transcription factor and mTOR kinase regulate the uptake and utilization of amino acids for protein and nucleic acid synthesis, as well as for the supply of intermediates to the mitochondrial Krebs cycle. However, the relationship between cellular signaling and metabolism is not unidirectional. Cells, by sensing levels of intracellular metabolites and the status of key metabolic pathways, can exert feedback control on signal transduction networks through multiple types of metabolite-derived protein modifications. These mechanisms allow cells to coordinate growth and division with their metabolic activity. © 2012 Cold Spring Harbor Laboratory Press; all rights reserved.
Keywords: signal transduction; protein kinase b; animal; metabolism; animals; cell division; oxygen; protein tyrosine kinase; phosphatidylinositol 3 kinase; proto-oncogene proteins c-akt; amino acid; glucose; protein-tyrosine kinases; amino acids; glycolysis; hypoxia inducible factor 1; hypoxia-inducible factor 1; phosphatidylinositol 3-kinases
Journal Title: Cold Spring Harbor Perspectives in Medicine
Volume: 4
Issue: 7
ISSN: 2157-1422
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2012-07-01
Start Page: a006783
Language: English
DOI: 10.1101/cshperspect.a006783
PROVIDER: scopus
PUBMED: 22687276
PMCID: PMC3385956
DOI/URL:
Notes: --- - "Export Date: 1 August 2012" - "Source: Scopus"
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  1. Patrick Shea Ward
    16 Ward
  2. Craig Bernie Thompson
    141 Thompson