An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer Journal Article
| Authors: | Vieweg, J.; Heston, W. D. W.; Gilboa, E.; Fair, W. R. |
| Article Title: | An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer |
| Abstract: | In order to develop an animal model that more closely simulates the organ environment and metastatic routes of human prostatic cancer, R3327‐MatLyLu tumors were induced by orthotopic implantation in the ventral prostatic lobe of Copenhagen rats. This procedure reproducibly resulted in metastatic spread of the intraprostatic tumor to the pelvic and retroperitoneal lymph nodes, and invariably to the lungs. Further, a tumor recurrence model was established using an approach that combined orthotopic tumor implantation and subsequent surgical resection of the primary tumor. When prostatectomy was carried out 4 days or more after induction, tumors recurred locally in all animals. The surgical procedures described may provide an animal model to test the in vivo response to experimental adjuvant treatment protocols for advanced prostate cancer. Immunological studies are now in progress using cytokine gene‐modified prostatic tumor cells as cellular antitumor vaccines in orthotopically established R3327‐MatLyLu tumors. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | controlled study; cancer recurrence; nonhuman; comparative study; lymph node metastasis; pelvis lymph node; lymphatic metastasis; animal cell; animal; animal tissue; neoplasm recurrence, local; lung neoplasms; animal model; cancer model; prostatic neoplasms; prostatectomy; rat; rats; neoplasm transplantation; prostate carcinoma; cancer transplantation; rats, inbred strains; prostatic carcinoma; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; transplantation, heterotopic; orthotopic implantation; tumor recurrence model |
| Journal Title: | Prostate |
| Volume: | 24 |
| Issue: | 6 |
| ISSN: | 0270-4137 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1994-06-01 |
| Start Page: | 291 |
| End Page: | 298 |
| Language: | English |
| DOI: | 10.1002/pros.2990240604 |
| PROVIDER: | scopus |
| PUBMED: | 8208623 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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