Immunotherapy of prostate cancer in the Dunning rat model: Use of cytokine gene modified tumor vaccines Journal Article

  


Authors: Vieweg, J.; Rosenthal, F. M.; Heston, W. D. W.; Fair, W. R.; Gansbacher, B.; Gilboa, E.
Article Title: Immunotherapy of prostate cancer in the Dunning rat model: Use of cytokine gene modified tumor vaccines
Abstract: Adenocarcinoma of the prostate is the most common cancer in men. The majority of cancers are discovered once they have already metastasized, and there is no effective therapy for prostatic cancer at this stage. The use of cytokine-secreting tumor cell preparations as therapeutic vaccines for the treatment of advanced prostate cancer was investigated in the Dunning rat R3327-MatLyLu prostatic tumor model. IL-2 secreting, irradiated, tumor cell preparations were capable of curing animals with s.c. established tumors, and induced immunological memory that protected animals from subsequent tumor challenge. Immunotherapy was less effective when tumors were induced orthotopically, but nevertheless led to improved outcome, significantly delaying, and occasionally preventing, recurrence of tumors after resection of the cancerous prostate. Granulocyte-macrophage colony stimulating factor secreting tumor cell preparations were less effective, and interferon-γ) secreting cells had only a marginal effect Induction of a potent immune response in tumor bearing animals against the nonimmunogenic MatLyLu tumor supports the view that active immunotherapy warrants further investigation as a potential therapeutic approach to prostate cancer. © 1994, American Association for Cancer Research. All rights reserved.
Keywords: cancer survival; controlled study; cancer recurrence; advanced cancer; nonhuman; adenocarcinoma; animals; mice; cell division; interleukin 2; cancer immunotherapy; tumor volume; cell line; animal experiment; animal model; tumor cells, cultured; transfection; cancer research; prostatic neoplasms; immunotherapy; kinetics; cytotoxicity, immunologic; rats; prostate adenocarcinoma; tumor vaccine; interleukin-2; interferon type ii; humans; male; priority journal; article
Journal Title: Cancer Research
Volume: 54
Issue: 7
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 1994-04-01
Start Page: 1760
End Page: 1765
Language: English
PROVIDER: scopus
PUBMED: 8137291
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028297315&partnerID=40&md5=73ccf65eb534105b75a8564ef65f1016
Notes: Source: Scopus
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MSK Authors
  1. Warren Heston
    136 Heston
  2. William R Fair
    342 Fair
  3. Bernd Gansbacher
    62 Gansbacher
  4. Eli Gilboa
    46 Gilboa
  5. Felicia M. Rosenthal
    11 Rosenthal
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