Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines Journal Article
| Authors: | Saito, S.; Bannerji, R.; Gansbacher, B.; Rosenthal, F. M.; Romanenko, P.; Heston, W. D. W.; Fair, W. R.; Gilboa, E. |
| Article Title: | Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines |
| Abstract: | This study explored the use of cytokine gene-modified tumor cells as cellular vaccines for the treatment of bladder cancer. The mouse MBT-2 tumor is an excellent model for human bladder cancer. This carcinogen-induced tumor of bladder origin resembles human bladder cancer in its etiology and histology and responds to treatment in a manner similar to that of its human counterpart In a previous study we have shown that interleukin 2 (IL-2)-secreting, irradiated, MBT-2 cell preparations were capable of curing animals from orthotopically established tumors and engendered protective immunological memory in the cured animals. In this study we have compared the effectiveness of several cytokines and found that while IL-1α, IL-1β, and γ-interferon were only weakly effective in the therapeutic vaccination protocol, granulocyte-macrophage colony-stimulating factor was almost as effective as but not superior to IL-2, as reported previously for another tumor model system. Induction of cytotoxic T-lymphocyte correlated only poorly with the therapeutic benefit of the cytokine gene-modified tumor cell preparations, questioning its prognostic value for the development of improved genetically modified tumor vaccines. © 1994, American Association for Cancer Research. All rights reserved. |
| Keywords: | immunohistochemistry; controlled study; nonhuman; mouse; animals; mice; animal tissue; interleukin 2; cancer immunotherapy; granulocyte macrophage colony stimulating factor; interleukin 1beta; animal experiment; animal model; transfection; bladder cancer; urinary bladder neoplasms; genetic vectors; lymphocyte activation; immunotherapy; gamma interferon; vaccination; cytotoxic t lymphocyte; t-lymphocytes, cytotoxic; disease models, animal; interleukin 1alpha; t lymphocyte activation; suppressor cell; helper cell; interleukin-2; interleukin-1; mice, inbred c3h; granulocyte-macrophage colony-stimulating factor; interferon type ii; female; priority journal; article |
| Journal Title: | Cancer Research |
| Volume: | 54 |
| Issue: | 13 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1994-07-01 |
| Start Page: | 3516 |
| End Page: | 3520 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 8012975 |
| DOI/URL: | |
| Notes: | Source: Scopus |
Citation Impact
Related MSK Work