Unilateral pulmonary artery occlusion inhibits growth of metastatic sarcoma in the rat lung Journal Article


Authors: Wang, H. Y.; Ng, B.; Ahrens, C.; Burt, M.
Article Title: Unilateral pulmonary artery occlusion inhibits growth of metastatic sarcoma in the rat lung
Abstract: Tumors depend on their blood supply for growth. The blood supply to metastatic neoplasia of lung is usually from the pulmonary circulation or both the pulmonary and systemic circulation. The antineoplastic effect of pulmonary artery occlusion was investigated in a rat model of methylcholanthrene‐induced metastatic pulmonary sarcoma. Left pulmonary artery ligation was performed on day 7 after tumor inoculation, and animals were sacrificed on day 14. The tumor burden of the left lung decreased 44% when compared with the control group. The survival of non‐tumor‐bearing rats undergoing left pulmonary artery ligation for 24 hours followed by right pneumonectomy after 2 weeks was also studied. No significant lung damage after a period of left pulmonary artery ligation was seen, as evidenced by both survival after contralateral right pneumonectomy and histology. Balloon occlusion of pulmonary artery, together with regional chemotherapy for patients with lung metastases, may warrant investigation. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
Keywords: cancer chemotherapy; cancer survival; controlled study; cancer growth; nonhuman; animals; animal tissue; lung neoplasms; animal experiment; animal model; antineoplastic activity; vascularization; sarcoma; lung metastasis; fibrosarcoma; rat; lung; rats; disease models, animal; ligation; pulmonary artery; random allocation; rats, inbred f344; metastatic tumor; methylcholanthrene; lung circulation; male; priority journal; article; pulmonary artery occlusion
Journal Title: Journal of Surgical Oncology
Volume: 57
Issue: 3
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 1994-11-01
Start Page: 183
End Page: 186
Language: English
DOI: 10.1002/jso.2930570309
PROVIDER: scopus
PUBMED: 7967607
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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  1. Michael E. Burt
    187 Burt
  2. Bruce Ng
    23 Ng