Trends in the susceptibility of tuberculosis in New York City, 1987-1991 Journal Article


Authors: Sepkowitz, K. A.; Telzak, E. E.; Recalde, S.; Armstrong, D.; New York City Area Tuberculosis Working Group
Article Title: Trends in the susceptibility of tuberculosis in New York City, 1987-1991
Abstract: The annual number of cases of tuberculosis in New York City has increased since 1978. In addition, in 1991 a 1-month survey of cases of tuberculosis in New York City found that 33% of all cases were resistant to at least one drug. To determine susceptibility trends from 1987 to 1991, a period during which an unprecedented rise in resistant tuberculosis occurred in New York City, we reviewed the microbiology records of 44 New York City hospitals (comprising >; 14, 000 cases). The percentage of cases resistant to at least one drug rose from 19% in 1987 to 28% in 1991, and the percentage of cases resistant to isoniazid rose from 13% in 1987 to 23% in 1991, while resistance to at least both isoniazid and rifampin rose from 6% to 14%. The rise of multidrug-resistant tuberculosis occurred in all four surveyed boroughs (counties) of New York City. These data demonstrate how rapidly multidrug-resistant tuberculosis can appear, and they suggest that initial empirical regimens should be broadened at certain hospitals. © 1994 by The University of Chicago.
Keywords: retrospective studies; major clinical study; united states; comparative study; human immunodeficiency virus infection; incidence; drug resistance; risk factor; time factors; mycobacterium tuberculosis; patient compliance; bias (epidemiology); disease predisposition; rifampicin; infection risk; multidrug resistance; tuberculosis; streptomycin; antitubercular agents; lung tuberculosis; drug resistance, microbial; ethambutol; isoniazid; human; priority journal; article; tuberculosis, multidrug-resistant
Journal Title: Clinical Infectious Diseases
Volume: 18
Issue: 5
ISSN: 1058-4838
Publisher: Oxford University Press  
Date Published: 1994-05-01
Start Page: 755
End Page: 759
Language: English
DOI: 10.1093/clinids/18.5.755
PROVIDER: scopus
PUBMED: 8075265
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. Kent A Sepkowitz
    270 Sepkowitz
  2. Donald Armstrong
    229 Armstrong
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