Molecular epidemiology of tuberculosis among eight hospitals in New York City, 1996-1997 Journal Article

Authors: Magnani, J.; Mathema, B.; Berger, J.; Brown, S.; David, M.; Glatt, A.; Pujol, F.; Segal-Maurer, S.; Riley, L. W.; Kreiswirth, B. N.; Sepkowitz, K. A.
Article Title: Molecular epidemiology of tuberculosis among eight hospitals in New York City, 1996-1997
Abstract: Objective: To determine the molecular epidemiology of tuberculosis isolated from patients cared for at eight hospitals scattered throughout New York City. Materials and Methods: Cases of tuberculosis occurring in 1996 and 1997 at collaborating hospitals were identified, and demographic data were extracted from patient charts. All available isolates were analyzed by IS6110 for genetic relatedness. The molecular fingerprints were compared both to each other and to the larger repository of strains from New York City developed and maintained at the Public Health Research Institute. Results: One hundred and eighty cases were fully characterized. Compared with New York City cases, study patients were more likely to be Asian and less likely to be non-Hispanic blacks. Overall, 97 (54%) of the cases were clustered with respect to other study strains or with respect to the other New York City isolates. Clustered strains were significantly more likely to be from non-Hispanic blacks or patients born in the United States. The largest cluster (n = 17) was the "W" strain previously associated with an outbreak of multidrug-resistant tuberculosis in New York City. In the current study, the majority of W strain isolates were fully drug-susceptible. Conclusions: High rates of genetically related tuberculosis continue to occur among patients in New York City, in spite of improved control of nosocomial outbreaks and dramatic decreases in the overall case rates. The use of molecular techniques to suggest patterns of transmission has become essential in developing and assessing routine tuberculosis control strategies.
Keywords: adult; aged; middle aged; major clinical study; united states; cluster analysis; genotype; time factors; hospital; mycobacterium tuberculosis; new york city; dna fingerprinting; molecular epidemiology; new york; bacterial dna; bacterium culture; tuberculosis; disease transmission; humans; human; male; female; article; patterns of transmission
Journal Title: International Journal of Infectious Diseases
Volume: 5
Issue: 3
ISSN: 1201-9712
Publisher: Elsevier Science, Inc.  
Date Published: 2001-01-01
Start Page: 126
End Page: 132
Language: English
DOI: 10.1016/s1201-9712(01)90086-4
PUBMED: 11724668
PROVIDER: scopus
Notes: Export Date: 21 May 2015 -- Source: Scopus
Citation Impact
MSK Authors
  1. Kent A Sepkowitz
    270 Sepkowitz