Tuberculosis symposium: Emerging problems and promise Journal Article
| Authors: | Ellner, J. J.; Hinman, A. R.; Dooley, S. W.; Fischl, M. A.; Sepkowitz, K. A.; Goldberger, M. J.; Shinnick, T. M.; Iseman, M. D.; Jacobs, W. R. Jr |
| Article Title: | Tuberculosis symposium: Emerging problems and promise |
| Abstract: | Between 1985 and 1991, 39, 000 cases of tuberculosis occurred in excess of those expected based on previous trends. Immigration from high-prevalence countries, coinfection with human immunodeficiency virus (HIV), and outbreaks in congregative facilities are most responsible for the increase. Coincident with the increase in tuberculosis, outbreaks of multidrug resistant (MDR) tuberculosis have occurred. Clinical and epidemiologic data support nosocomial transmission. MDR tuberculosis occurred late in the course of HIV infection and was refractory to treatment. Compounding the problems of rising incidence and increasing resistance was the sudden recognition of shortages of antituberculous drugs. The problems currently posed by tuberculosis require new approaches to diagnosis and rapid sensitivity testing as well as assuring an adequate supply of licensed drugs and development of new drugs. A number of steps have been taken by governmental agencies to assure that the challenge is met. © 1993 by The University of Chicago. |
| Keywords: | clinical feature; mortality; nonhuman; united states; conference paper; human immunodeficiency virus infection; molecular genetics; polymerase chain reaction; bcg vaccine; luciferase; enzyme linked immunosorbent assay; health care cost; mycobacterium tuberculosis; dna; ciprofloxacin; health care personnel; new york city; thorax radiography; hospital infection; quinoline derived antiinfective agent; rifampicin; drug sensitivity; pentamidine; multidrug resistance; tuberculosis; hiv infections; ofloxacin; disease transmission; rifabutin; drug industry; rna polymerase; streptomycin; kanamycin; restriction fragment length polymorphism; drug resistance, microbial; tuberculin test; ethambutol; isoniazid; pneumocystis carinii; tuberculostatic agent; pyrazinamide; tuberculin; cycloserine; tuberculosis control; human; priority journal; ethionamide; aminosalicylic acid; capreomycin; sparfloxacin |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 168 |
| Issue: | 3 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1993-09-01 |
| Start Page: | 537 |
| End Page: | 551 |
| Language: | English |
| DOI: | 10.1093/infdis/168.3.537 |
| PUBMED: | 8354898 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
