Tuberculosis in the AIDS era Journal Article
| Authors: | Sepkowitz, K. A.; Raffalli, J.; Riley, L.; Kiehn, T. E.; Armstrong, D. |
| Article Title: | Tuberculosis in the AIDS era |
| Abstract: | A resurgence of tuberculosis has occurred in recent years in the United States and abroad. Deteriorating public health services, increasing numbers of immigrants from countries of endemicity and coinfection with the human immunodeficiency virus (HIV) have contributed to the rise in the number of cases diagnosed in the United States. Outbreaks of resistant tuberculosis which responds poorly to therapy, have occurred in hospitals and other settings, affecting patients and health care workers. This review covers the pathogenesis, epidemiology, clinical presentation, laboratory diagnosis, and treatment of Mycobacterium tuberculosis infection and disease. In addition public health and hospital infection control strategies are detailed. Newer approaches to epidemiologic investigation, including use of restriction fragment length polymorphism analysis, are discussed. Detailed consideration of the interaction between HIV infection and tuberculosis is given. We also review the latest techniques in laboratory evaluation, including the radiometric culture system DNA probes, and PCR. Current recommendations for therapy of tuberculosis, including multidrug-resistant tuberculosis, are given. Finally, the special problem of prophylaxis of persons exposed to multidrug-resistant tuberculosis is considered. |
| Keywords: | clinical feature; pathogenesis; review; united states; human immunodeficiency virus infection; laboratory diagnosis; polymerase chain reaction; bcg vaccine; liver toxicity; gastrointestinal symptom; peripheral neuropathy; kidney failure; arthralgia; fever; hyperuricemia; rash; antibiotic resistance; mycobacterium tuberculosis; warfarin; human immunodeficiency virus; acquired immune deficiency syndrome; methadone; hospital infection; anticonvulsive agent; mycobacterium; macrolide; quinoline derived antiinfective agent; rifampicin; antibiotic sensitivity; infection control; antibiotic prophylaxis; oral contraceptive agent; dapsone; tuberculosis; cross infection; intravenous drug administration; fluid retention; rifabutin; agitation; ototoxicity; uveitis; central nervous system disease; intramuscular drug administration; bcg vaccination; streptomycin; institutional care; aids-related opportunistic infections; pyridoxine; clofazimine; ethambutol; isoniazid; optic nerve disease; tuberculostatic agent; pyrazinamide; cycloserine; prison; human; tuberculosis, multidrug-resistant; ethionamide; aminosalicylic acid; capreomycin; thioacetazone |
| Journal Title: | Clinical Microbiology Reviews |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 0893-8512 |
| Publisher: | American Society for Microbiology |
| Date Published: | 1995-04-01 |
| Start Page: | 180 |
| End Page: | 199 |
| Language: | English |
| PUBMED: | 7621399 |
| PROVIDER: | scopus |
| PMCID: | PMC172855 |
| DOI: | 10.1128/CMR.8.2.180 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 28 August 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work