Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila Journal Article

  

Authors:	Brummel, T. J.; Twombly, V.; Marqués, G.; Wrana, J. L.; Newfeld, S. J.; Attisano, L.; Massagué, J.; O'Connor, M. B.; Gelbart, W. M.
Article Title:	Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila
Abstract:	The dpp/BMP family of TGFβ-related factors controls numerous events in pattern formation and morphogenesis. How these polypeptide signals are received and transduced by target cells is largely unknown. We combine molecular and genetic approaches to establish that the Drosophila saxophone (sax) gene encodes a dpp receptor. We compare the structural properties and expression patterns of sax with a second dpp receptor encoded by the thick veins (tkv) gene. While the sax gene is expressed ubiquitously, tkv is expressed in a highly localized and dynamic pattern during development. Some, but not all, of the tkv expression pattern parallels that of dpp. Ubiquitous expression of a tkv transgene rescues both tkv and sax loss-of-function mutations. Thus, there is at least partial functional overlap of the sax and tkv receptors in vivo. We consider these observations in terms of possible ligand-receptor interactions during Drosophila development. © 1994.
Keywords:	gene sequence; mutation; nonhuman; proteins; animals; gene expression; bone morphogenetic protein; transforming growth factor beta; drosophila; morphogenesis; gene expression regulation; cloning, molecular; amino acid sequence; molecular sequence data; rna, messenger; protein-serine-threonine kinases; signal peptide; transgene; receptors, transforming growth factor beta; target cell; drosophila proteins; genetic code; ligand binding; gene structure; receptors, cell surface; xenopus; sequence analysis, dna; bone morphogenetic proteins; genes, insect; crosses, genetic; humans; male; female; priority journal; article; insect hormones
Journal Title:	Cell
Volume:	78
Issue:	2
ISSN:	0092-8674
Publisher:	Cell Press
Date Published:	1994-07-29
Start Page:	251
End Page:	261
Language:	English
DOI:	10.1016/0092-8674(94)90295-x
PROVIDER:	scopus
PUBMED:	8044839
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028103859&doi=10.1016%2f0092-8674%2894%2990295-X&partnerID=40&md5=df0421e54d152220635e05b8d6e6cb4f
Notes:	Export Date: 14 January 2019 -- Article -- Source: Scopus

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