The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development Journal Article

  


Authors: Estevez, M.; Attisano, L.; Wrana, J. L.; Albert, P. S.; Massagué, J.; Riddle, D. L.
Article Title: The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development
Abstract: THE bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth fact-or-β (TGF-β) superfamily1,2. This group, including the Drosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development3,4. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva5. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-β receptor serine/ threonine kinases. When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family. © 1993 Nature Publishing Group.
Keywords: unclassified drug; nonhuman; proteins; animal; mammalia; bone morphogenetic protein; cell line; protein binding; dna; amino acid sequence; molecular sequence data; sequence homology, amino acid; protein-serine-threonine kinases; recombinant proteins; base sequence; caenorhabditis elegans; receptor protein-tyrosine kinases; monkey; receptor binding; larva; bone morphogenetic proteins; growth; animals, genetically modified; dna transposable elements; growth factor receptor; haplorhini; helminth proteins; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; bone protein; parasite development
Journal Title: Nature
Volume: 365
Issue: 6447
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 1993-10-14
Start Page: 644
End Page: 649
Language: English
DOI: 10.1038/365644a0
PUBMED: 8413626
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027373733&doi=10.1038%2f365644a0&partnerID=40&md5=451fcbf86e9ac5b8ba57d28aef052605
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
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MSK Authors
  1. Joan Massague
    388 Massague
  2. Jeff Wrana
    39 Wrana
  3. Liliana Attisano
    30 Attisano
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